| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 8 |
|---|
| Ligand | BDBM21898 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_529509 (CHEMBL966653) |
|---|
| IC50 | 12±n/a nM |
|---|
| Citation |  Hall, JP; Kurdi, Y; Hsu, S; Cuozzo, J; Liu, J; Telliez, JB; Seidl, KJ; Winkler, A; Hu, Y; Green, N; Askew, GR; Tam, S; Clark, JD; Lin, LL Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem282:33295-304 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 8 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 8 |
|---|
| Synonyms: | C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 52916.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41279 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
|
|
|
|---|
| BDBM21898 |
|---|
| n/a |
|---|
| Name | BDBM21898 |
|---|
| Synonyms: | 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrile | CHEMBL436817 | Cyanoquinoline, 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13Cl2FN6 |
|---|
| Mol. Mass. | 427.262 |
|---|
| SMILES | Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
