Reaction Details |
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Target | MAP kinase-activated protein kinase 2 |
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Ligand | BDBM21898 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_529516 (CHEMBL966660) |
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IC50 | 48000±n/a nM |
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Citation | Hall, JP; Kurdi, Y; Hsu, S; Cuozzo, J; Liu, J; Telliez, JB; Seidl, KJ; Winkler, A; Hu, Y; Green, N; Askew, GR; Tam, S; Clark, JD; Lin, LL Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem282:33295-304 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MAP kinase-activated protein kinase 2 |
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Name: | MAP kinase-activated protein kinase 2 |
Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45579.87 |
Organism: | Homo sapiens (Human) |
Description: | P49137 |
Residue: | 400 |
Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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BDBM21898 |
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n/a |
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Name | BDBM21898 |
Synonyms: | 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrile | CHEMBL436817 | Cyanoquinoline, 11 |
Type | Small organic molecule |
Emp. Form. | C20H13Cl2FN6 |
Mol. Mass. | 427.262 |
SMILES | Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl |
Structure |
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