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TargetCyclin-dependent kinase 1
LigandBDBM50245620
Substrate/Competitorn/a
Meas. Tech.ChEMBL_511072 (CHEMBL1000364)
IC50 1700±n/a nM
Citation Smaill, JBBaker, ENBooth, RJBridges, AJDickson, JMDobrusin, EMIvanovic, IKraker, AJLee, HHLunney, EAOrtwine, DFPalmer, BDQuin, JSquire, CJThompson, AMDenny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 1
Name:Cyclin-dependent kinase 1
Synonyms:CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:Enzyme Subunit
Mol. Mass.:34101.08
Organism:Homo sapiens (Human)
Description:P06493
Residue:297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50245620
n/a
NameBDBM50245620
Synonyms:4-(2-chlorophenyl)-9-hydroxy-6-(2-morpholinoethyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL529669
TypeSmall organic molecule
Emp. Form.C26H22ClN3O4
Mol. Mass.475.924
SMILESOc1ccc2n(CCN3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Structure
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