Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50245341 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_511068 (CHEMBL1000360) | ||
IC50 | 14±n/a nM | ||
Citation | Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50245341 | |||
n/a | |||
Name | BDBM50245341 | ||
Synonyms: | 3-(4-(2,6-dichlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1H)-yl)-N-(2-(dimethylamino)ethyl)propanamide | CHEMBL461116 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H24Cl2N4O4 | ||
Mol. Mass. | 539.41 | ||
SMILES | CN(C)CCNC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(18.95,-7.42,;19.98,-6.27,;19.49,-4.8,;21.48,-6.57,;22.51,-5.42,;24.02,-5.73,;25.04,-4.58,;26.55,-4.89,;24.55,-3.12,;25.57,-1.97,;25.09,-.51,;23.61,-.04,;22.27,-.81,;20.93,-.04,;20.94,1.51,;19.6,2.28,;22.26,2.28,;23.6,1.52,;25.07,2,;25.69,3.41,;25.05,4.81,;23.55,5.13,;26.19,5.85,;27.52,5.09,;28.93,5.72,;27.21,3.58,;28.14,2.34,;27.52,.93,;25.99,.76,;29.67,2.52,;30.58,1.28,;29.97,-.13,;32.11,1.45,;32.73,2.87,;31.8,4.11,;30.28,3.93,;30.26,5.47,)| | ||
Structure |