Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50245258 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_511068 (CHEMBL1000360) | ||
IC50 | 62±n/a nM | ||
Citation | Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50245258 | |||
n/a | |||
Name | BDBM50245258 | ||
Synonyms: | 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(4-methylpiperazin-1-yl)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL452078 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H26Cl2N4O3 | ||
Mol. Mass. | 537.437 | ||
SMILES | CN1CCN(CCCn2c3ccc(O)cc3c3c4C(=O)NC(=O)c4c(cc23)-c2c(Cl)cccc2Cl)CC1 |(20.56,-23.44,;21.58,-22.29,;21.1,-20.83,;22.12,-19.69,;23.63,-20,;24.66,-18.84,;24.17,-17.38,;25.19,-16.23,;24.71,-14.77,;23.23,-14.3,;21.89,-15.07,;20.55,-14.3,;20.55,-12.76,;19.22,-11.99,;21.88,-11.98,;23.22,-12.75,;24.69,-12.26,;25.31,-10.85,;24.67,-9.45,;23.16,-9.14,;25.81,-8.41,;27.14,-9.17,;28.55,-8.54,;26.83,-10.68,;27.76,-11.92,;27.14,-13.34,;25.61,-13.51,;29.29,-11.75,;30.2,-12.99,;29.59,-14.4,;31.73,-12.81,;32.35,-11.4,;31.42,-10.16,;29.9,-10.34,;29.88,-8.8,;24.12,-21.46,;23.09,-22.61,)| | ||
Structure |