Ki Summary

Reaction Details

Report a problem with these data

Target

Wee1-like protein kinase

Ligand

BDBM50245621

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_511068 (CHEMBL1000360)

IC50

110±n/a nM

Citation

Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Wee1-like protein kinase

Name:

Wee1-like protein kinase

Synonyms:

Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN

Type:

PROTEIN

Mol. Mass.:

71599.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1445054

Residue:

646

Sequence:

MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY

BDBM50245621

n/a

Name

BDBM50245621

Synonyms:

4-(2,6-dichlorophenyl)-9-hydroxy-6-(2-morpholinoethyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL520071

Type

Small organic molecule

Emp. Form.

C26H21Cl2N3O4

Mol. Mass.

510.369

SMILES

Oc1ccc2n(CCN3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(19.14,-37.63,;20.47,-38.4,;20.47,-39.95,;21.8,-40.72,;23.13,-39.95,;24.61,-40.42,;25.09,-41.89,;24.06,-43.03,;24.53,-44.5,;23.51,-45.64,;23.98,-47.1,;25.49,-47.42,;26.52,-46.28,;26.05,-44.81,;25.51,-39.17,;27.05,-39.01,;27.68,-37.6,;26.76,-36.35,;27.08,-34.85,;28.49,-34.23,;25.76,-34.08,;24.61,-35.1,;23.11,-34.78,;25.23,-36.51,;24.61,-37.91,;23.13,-38.39,;21.8,-37.63,;29.21,-37.44,;30.11,-38.69,;29.48,-40.1,;31.64,-38.53,;32.27,-37.12,;31.36,-35.88,;29.83,-36.04,;29.82,-34.5,)|

Structure