Ki Summary

Reaction Details

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Target

Beta-lactamase

Ligand

BDBM50021954

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_522056 (CHEMBL1004914)

IC50

22700±n/a nM

Citation

Fonseca, F; Sarmento, AC; Henriques, I; Samyn, B; van Beeumen, J; Domingues, P; Domingues, MR; Saavedra, MJ; Correia, A Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. Antimicrob Agents Chemother51:4512-4 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Carbapenem-hydrolizing beta-lactamase SFC-1

Type:

PROTEIN

Mol. Mass.:

33593.82

Organism:

Serratia fonticola

Description:

ChEMBL_522056

Residue:

309

Sequence:

MSRTGRLSVFFSAIFPLLTLTNMAEAASQPPQVTVDKLKRLENDFGGRIGVYAIDTGSNK
TFGYRANERFPLCSSFKGFLAAAVLSKSQQQEGLLNQRIRYDNRVMEPHSPVTEKQITTG
MTVAELSAATLQYSDNGAANLLLEKLIGGPEGMTSFMRSIGDNVFRLDRWELELNSAIPG
DDRDTSTPKAVAESMQKLAFGNVLGLTERHQLMDWFKGNTTGGARIRASVPANWVVGDKT
GTCGVYGTANDYAVIWPVGHAPIVLAVYTSKPDKNSKHSDAVIADASRIVLESFNIDALR
MATGKSIGF

BDBM50021954

n/a

Name

BDBM50021954

Synonyms:

(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam) | CHEMBL403 | CP-45,899 | SULBACTAM | UNASYN | US20230322715, Compound ALK-09 | US9120808, Sulbactam sodium salt

Type

Small organic molecule

Emp. Form.

C8H11NO5S

Mol. Mass.

233.242

SMILES

CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O |r|

Structure