| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor alpha |
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| Ligand | BDBM18869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_533636 (CHEMBL969512) |
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| Ki | 7.18±n/a nM |
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| Citation |  Erion, MD; Cable, EE; Ito, BR; Jiang, H; Fujitaki, JM; Finn, PD; Zhang, BH; Hou, J; Boyer, SH; van Poelje, PD; Linemeyer, DL Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A104:15490-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor alpha |
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| Name: | Thyroid hormone receptor alpha |
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| Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 |
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| Type: | Receptor |
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| Mol. Mass.: | 54818.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. |
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| Residue: | 490 |
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| Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
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| BDBM18869 |
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| n/a |
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| Name | BDBM18869 |
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| Synonyms: | 2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}acetic acid | CHEMBL41036 | KB-141 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16Cl2O4 |
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| Mol. Mass. | 355.213 |
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| SMILES | CC(C)c1cc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)ccc1O |
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| Structure | 
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