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TargetGlycogen synthase kinase-3 alpha
LigandBDBM50186084
Substrate/Competitorn/a
Meas. Tech.ChEMBL_519479 (CHEMBL951785)
IC50 1300±n/a nM
Citation Logé, CTestard, AThiéry, VLozach, OBlairvacq, MRobert, JMMeijer, LBesson, T Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies. Eur J Med Chem43:1469-77 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 alpha
Name:Glycogen synthase kinase-3 alpha
Synonyms:GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha)
Type:Enzyme
Mol. Mass.:50991.79
Organism:Homo sapiens (Human)
Description:P49840
Residue:483
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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  Blast E-value cutoff:
BDBM50186084
n/a
NameBDBM50186084
Synonyms:CHEMBL210474 | N-(2-(dimethylamino)ethyl)-8-ethyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine | N-(2-Dimethylamino-ethyl)-8-ethyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine
TypeSmall organic molecule
Emp. Form.C16H20N6OS
Mol. Mass.344.435
SMILESCCn1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C
Structure
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