Reaction Details |
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Target | Glycogen synthase kinase-3 alpha |
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Ligand | BDBM50186084 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_519479 (CHEMBL951785) |
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IC50 | 1300±n/a nM |
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Citation | Logé, C; Testard, A; Thiéry, V; Lozach, O; Blairvacq, M; Robert, JM; Meijer, L; Besson, T Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies. Eur J Med Chem43:1469-77 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 alpha |
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Name: | Glycogen synthase kinase-3 alpha |
Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
Type: | Enzyme |
Mol. Mass.: | 50991.79 |
Organism: | Homo sapiens (Human) |
Description: | P49840 |
Residue: | 483 |
Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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BDBM50186084 |
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n/a |
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Name | BDBM50186084 |
Synonyms: | CHEMBL210474 | N-(2-(dimethylamino)ethyl)-8-ethyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine | N-(2-Dimethylamino-ethyl)-8-ethyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine |
Type | Small organic molecule |
Emp. Form. | C16H20N6OS |
Mol. Mass. | 344.435 |
SMILES | CCn1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C |
Structure |
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