| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lactoylglutathione lyase |
|---|
| Ligand | BDBM50241121 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_529831 (CHEMBL967534) |
|---|
| IC50 | 23000±n/a nM |
|---|
| Citation |  Takasawa, R; Takahashi, S; Saeki, K; Sunaga, S; Yoshimori, A; Tanuma, S Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem16:3969-75 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lactoylglutathione lyase |
|---|
| Name: | Lactoylglutathione lyase |
|---|
| Synonyms: | Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 20772.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q04760 |
|---|
| Residue: | 184 |
|---|
| Sequence: | MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
|
|
|
|---|
| BDBM50241121 |
|---|
| n/a |
|---|
| Name | BDBM50241121 |
|---|
| Synonyms: | (S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethylamino)-1-oxopropan-2-ylamino)-2-amino-5-oxopentanoic acid | CHEMBL218644 | S-p-bromobenzyl glutatione | S-p-bromobenzylglutathione |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H22BrN3O6S |
|---|
| Mol. Mass. | 476.342 |
|---|
| SMILES | N[C@@H](CCC(=O)N[C@@H](CSCc1ccc(Br)cc1)C(=O)NCC(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
