| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase |
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| Ligand | BDBM50270341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_530311 (CHEMBL980373) |
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| IC50 | 900000±n/a nM |
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| Citation |  Nowicki, MW; Tulloch, LB; Worralll, L; McNae, IW; Hannaert, V; Michels, PA; Fothergill-Gilmore, LA; Walkinshaw, MD; Turner, NJ Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem16:5050-61 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase |
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| Name: | Pyruvate kinase |
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| Synonyms: | KPYK_LEIME | PYK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54404.51 |
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| Organism: | Leishmania mexicana |
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| Description: | ChEMBL_530311 |
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| Residue: | 499 |
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| Sequence: | MSQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEY
HQTTINNVRQAAAELGVNIAIALDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKG
TKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNL
PGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKGRDIMIICKI
ENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQML
ESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNE
YVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIV
CVTTRLQTCRQLNITQGVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYVQTGDYCVVI
HADHKVKGYANQTRILLVE
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| BDBM50270341 |
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| n/a |
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| Name | BDBM50270341 |
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| Synonyms: | (2R,3S,4S,5R)-2-(hydroxymethyl)-5-(((R)-1-(4-methoxyphenyl)ethylamino)methyl)-tetrahydrofuran-3,4-diol | CHEMBL478291 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H23NO5 |
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| Mol. Mass. | 297.3468 |
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| SMILES | COc1ccc(cc1)[C@@H](C)NC[C@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |r| |
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| Structure | 
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