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TargetPyruvate kinase
LigandBDBM50270339
Substrate/Competitorn/a
Meas. Tech.ChEMBL_530311 (CHEMBL980373)
IC50 4300000±n/a nM
Citation Nowicki, MWTulloch, LBWorralll, LMcNae, IWHannaert, VMichels, PAFothergill-Gilmore, LAWalkinshaw, MDTurner, NJ Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem16:5050-61 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Pyruvate kinase
Name:Pyruvate kinase
Synonyms:KPYK_LEIME | PYK
Type:PROTEIN
Mol. Mass.:54404.51
Organism:Leishmania mexicana
Description:ChEMBL_530311
Residue:499
Sequence:
MSQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEY
HQTTINNVRQAAAELGVNIAIALDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKG
TKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNL
PGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKGRDIMIICKI
ENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQML
ESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNE
YVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIV
CVTTRLQTCRQLNITQGVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYVQTGDYCVVI
HADHKVKGYANQTRILLVE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50270339
n/a
NameBDBM50270339
Synonyms:(2R,3S,4S,5R)-2-((cyclobutylamino)methyl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol | CHEMBL472122
TypeSmall organic molecule
Emp. Form.C10H19NO4
Mol. Mass.217.2622
SMILESOC[C@H]1O[C@H](CNC2CCC2)[C@@H](O)[C@@H]1O |r|
Structure
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