Reaction Details |
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Target | ATP-dependent 6-phosphofructokinase |
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Ligand | BDBM50270350 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_530309 (CHEMBL980371) |
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IC50 | 23000±n/a nM |
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Citation | Nowicki, MW; Tulloch, LB; Worralll, L; McNae, IW; Hannaert, V; Michels, PA; Fothergill-Gilmore, LA; Walkinshaw, MD; Turner, NJ Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem16:5050-61 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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ATP-dependent 6-phosphofructokinase |
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Name: | ATP-dependent 6-phosphofructokinase |
Synonyms: | 6-phospho-1-fructokinase | PFKA_TRYBB | pfk |
Type: | PROTEIN |
Mol. Mass.: | 53537.94 |
Organism: | Trypanosoma brucei |
Description: | ChEMBL_1288121 |
Residue: | 487 |
Sequence: | MAVESRSRVTSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKYSSRTEFRDKTDYIM
YNPRPRDEPSSENPVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSIT
LTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSRGPQDPKE
MVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFG
FQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENPI
SEQEVMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAF
LKANKSRYPDSTVKYIDPSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHN
NYILVPIKVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNRDRL
HEELAKL
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BDBM50270350 |
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n/a |
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Name | BDBM50270350 |
Synonyms: | 2,5-Anhydro-1-deoxy-1-(3,4-dichlorobenzylamino)-D-3,4-dichlorobenzylmannonamide | CHEMBL479201 |
Type | Small organic molecule |
Emp. Form. | C20H20Cl4N2O4 |
Mol. Mass. | 494.196 |
SMILES | O[C@H]1[C@H](O)[C@H](O[C@@H]1CNCc1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(Cl)c(Cl)c1 |r| |
Structure |
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