| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Regulatory protein E2 |
|---|
| Ligand | BDBM50035218 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_532976 (CHEMBL989646) |
|---|
| Kd | 1050±n/a nM |
|---|
| Citation |  Saitoh, T; Kuramochi, K; Imai, T; Takata, K; Takehara, M; Kobayashi, S; Sakaguchi, K; Sugawara, F Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem16:5815-25 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Regulatory protein E2 |
|---|
| Name: | Regulatory protein E2 |
|---|
| Synonyms: | E2 | VE2_HPV1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45494.82 |
|---|
| Organism: | Human papillomavirus type 1a |
|---|
| Description: | ChEMBL_532977 |
|---|
| Residue: | 401 |
|---|
| Sequence: | MENLSSRLDLLQEQLMNLYEQDSKLIEDQIKQWNLIRQEQVLFHFARKNGVMRIGLQAVP
SLASSQEKAKTAIEMVLHLESLKDSPYGTEDWSLQDTSRELFLAPPAGTFKKSGSTLEVT
YDNNPDNQTRHTIWNHVYYQNGDDVWRKVSSGVDAVGVYYLEHDGYKNYYVLFAEEASKY
STTGQYAVNYRGKRFTNVMSSTSSPRAAGAPAVHSDYPTLSESDTAQQSTSIDYTELPGQ
GETSQVRQRQQKTPVRRRPYGRRRSRSPRGGGRREGESTPSRTPGSVPSARDVGSIHTTP
QKGHSSRLRRLLQEAWDPPVVCVKGGANQLKCLRYRLKASTQVDFDSISTTWHWTDRKNT
ERIGSARMLVKFIDEAQREKFLERVALPRSVSVFLGQFNGS
|
|
|
|---|
| BDBM50035218 |
|---|
| n/a |
|---|
| Name | BDBM50035218 |
|---|
| Synonyms: | CHEMBL61 | PODOFILOX | Podophyllinic acid lactone | Podophyllotoxin (PTOX) | podophyllotoxin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22O8 |
|---|
| Mol. Mass. | 414.4053 |
|---|
| SMILES | COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
