Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50261244

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_555922 (CHEMBL956658)

40±n/a nM

Citation

Betz, SF; Zhu, YF; Chen, C; Struthers, RS Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem51:3331-48 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

37749.45

Organism:

Homo sapiens (Human)

Description:

P30968

Residue:

328

Sequence:

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50261244

n/a

Name

BDBM50261244

Synonyms:

6-((R)-2-amino-2-phenylethyl)-8-(2-fluoro-3-methoxyphenyl)-3-(2-fluorophenyl)-2,3-dihydro-6H-thiazolo[3,2-f]pyrimidine-5,7-dione | CHEMBL468552

Type

Small organic molecule

Emp. Form.

C27H23F2N3O3S

Mol. Mass.

507.552

SMILES

COc1cccc(c1F)-c1c2SCC(c3ccccc3F)n2c(=O)n(C[C@H](N)c2ccccc2)c1=O |r,wD:26.29,(16.83,-7.23,;15.49,-8.01,;15.5,-9.55,;16.84,-10.32,;16.83,-11.86,;15.5,-12.63,;14.17,-11.85,;14.17,-10.32,;12.83,-9.55,;12.84,-12.62,;12.84,-14.16,;13.98,-15.19,;13.36,-16.59,;11.83,-16.43,;10.8,-17.57,;9.29,-17.25,;8.26,-18.4,;8.74,-19.86,;10.26,-20.18,;11.28,-19.03,;12.78,-19.34,;11.51,-14.93,;10.17,-14.16,;8.84,-14.92,;10.18,-12.62,;8.84,-11.85,;7.51,-12.62,;7.51,-14.16,;6.17,-11.86,;4.84,-12.63,;3.5,-11.86,;3.51,-10.31,;4.83,-9.54,;6.17,-10.31,;11.5,-11.84,;11.5,-10.3,)|

Structure