| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase 2 |
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| Ligand | BDBM50168761 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_553563 (CHEMBL958746) |
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| IC50 | >1000±n/a nM |
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| Citation |  Friesen, RW; Mancini, JA Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target. J Med Chem51:4059-67 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase 2 |
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| Name: | Prostaglandin E synthase 2 |
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| Synonyms: | C9orf15 | PGES2 | PGES2_HUMAN | PTGES2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41955.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H7Z7 |
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| Residue: | 377 |
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| Sequence: | MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLG
AAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFL
DFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD
WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQ
DNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQ
PWYLRVERAITEASPAH
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| BDBM50168761 |
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| n/a |
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| Name | BDBM50168761 |
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| Synonyms: | 3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid | 3-[1-(4-Chloro-benzyl)-5-(2-fluoro-biphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethyl-propionic acid | CHEMBL182032 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H29ClFNO2 |
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| Mol. Mass. | 526.04 |
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| SMILES | Cc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(cc12)-c1ccc(c(F)c1)-c1ccccc1 |
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| Structure | 
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