| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50271448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_556415 (CHEMBL954907) |
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| Ki | 6500±n/a nM |
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| Citation |  Gasse, C; Douguet, D; Huteau, V; Marchal, G; Munier-Lehmann, H; Pochet, S Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity. Bioorg Med Chem16:6075-85 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50271448 |
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| n/a |
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| Name | BDBM50271448 |
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| Synonyms: | 5-[5-Chloro-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl-methyl)-phenyl]-butanoic acid | CHEMBL520293 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN2O4 |
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| Mol. Mass. | 322.744 |
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| SMILES | OC(=O)CCCc1ccc(Cn2cc(Cl)c(=O)[nH]c2=O)cc1 |
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| Structure | 
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