Reaction Details |
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Target | Beta-secretase 2 |
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Ligand | BDBM50271627 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_556481 (CHEMBL956476) |
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IC50 | 51±n/a nM |
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Citation | Cumming, JN; Le, TX; Babu, S; Carroll, C; Chen, X; Favreau, L; Gaspari, P; Guo, T; Hobbs, DW; Huang, Y; Iserloh, U; Kennedy, ME; Kuvelkar, R; Li, G; Lowrie, J; McHugh, NA; Ozgur, L; Pan, J; Parker, EM; Saionz, K; Stamford, AW; Strickland, C; Tadesse, D; Voigt, J; Wang, L; Wu, Y; Zhang, L; Zhang, Q Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors. Bioorg Med Chem Lett18:3236-41 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 2 |
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Name: | Beta-secretase 2 |
Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
Type: | Protein |
Mol. Mass.: | 56171.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Z0 |
Residue: | 518 |
Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
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BDBM50271627 |
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n/a |
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Name | BDBM50271627 |
Synonyms: | CHEMBL507651 | N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | N1-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-4-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-5-methyl-N3,N3-dipropylisophthalamide |
Type | Small organic molecule |
Emp. Form. | C34H40F2N4O4 |
Mol. Mass. | 606.7026 |
SMILES | CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@@H]1NCN(Cc2ccccc2)C1=O |r| |
Structure |
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