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TargetUrotensin II receptor
LigandBDBM50244020
Substrate/Competitorn/a
Meas. Tech.ChEMBL_555221
Ki 0.3±n/a nM
Citation McAtee JJDodson JWDowdell SEErhard KGirard GRGoodman KBHilfiker MAJin JSehon CASha DShi DWang FWang GZWang NWang YViet AQYuan CCZhang DAiyar NVBehm DJCarballo LHEvans CAFries HENagilla RRoethke TJXu XDouglas SANeeb MJ Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles. Bioorg Med Chem Lett 18:3716-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urotensin II receptor
Name:Urotensin II receptor
Synonyms:G-protein coupled receptor 14 | UR-II-R | Urotensin-II
Type:Enzyme Catalytic Domain
Mol. Mass.:42159.71
Organism:Homo sapiens (Human)
Description:Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
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  Blast E-value cutoff:
BDBM50244020
n/a
NameBDBM50244020
Synonyms:4'-[1-({2-[Cyanomethyl-(3,4-dichloro-phenyl)-amino]-acetyl}-methyl-amino)-2-pyrrolidin-1-yl-ethyl]-biphenyl-3-carboxylic acid amide | CHEMBL453587
TypeSmall organic molecule
Emp. Form.C30H31Cl2N5O2
Mol. Mass.564.505
SMILESCN(C(CN1CCCC1)c1ccc(cc1)-c1cccc(c1)C(N)=O)C(=O)CN(CC#N)c1ccc(Cl)c(Cl)c1
Structure
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