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TargetCytochrome P450 2D6
LigandBDBM50244019
Substrate/Competitorn/a
Meas. Tech.ChEMBL_555224 (CHEMBL965361)
IC50 6200±n/a nM
Citation McAtee, JJDodson, JWDowdell, SEErhard, KGirard, GRGoodman, KBHilfiker, MAJin, JSehon, CASha, DShi, DWang, FWang, GZWang, NWang, YViet, AQYuan, CCZhang, DAiyar, NVBehm, DJCarballo, LHEvans, CAFries, HENagilla, RRoethke, TJXu, XDouglas, SANeeb, MJ Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles. Bioorg Med Chem Lett18:3716-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50244019
n/a
NameBDBM50244019
Synonyms:4'-[1-({2-[(3,4-Dichloro-phenyl)-(2-methoxy-ethyl)-amino]-acetyl}-methyl-amino)-2-pyrrolidin-1-yl-ethyl]-biphenyl-4-carboxylic acid amide | CHEMBL453067
TypeSmall organic molecule
Emp. Form.C31H36Cl2N4O3
Mol. Mass.583.549
SMILESCOCCN(CC(=O)N(C)C(CN1CCCC1)c1ccc(cc1)-c1ccc(cc1)C(N)=O)c1ccc(Cl)c(Cl)c1
Structure
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