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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucagon receptor | ||
| Ligand | BDBM50244122 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_491826 (CHEMBL945216) | ||
| IC50 | 4±n/a nM | ||
| Citation |  Kim, RM; Chang, J; Lins, AR; Brady, E; Candelore, MR; Dallas-Yang, Q; Ding, V; Dragovic, J; Iliff, S; Jiang, G; Mock, S; Qureshi, S; Saperstein, R; Szalkowski, D; Tamvakopoulos, C; Tota, L; Wright, M; Yang, X; Tata, JR; Chapman, K; Zhang, BB; Parmee, ER Discovery of potent, orally active benzimidazole glucagon receptor antagonists. Bioorg Med Chem Lett18:3701-5 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucagon receptor | |||
| Name: | Glucagon receptor | ||
| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 54026.92 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P47871 | ||
| Residue: | 477 | ||
| Sequence: |
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| BDBM50244122 | |||
| n/a | |||
| Name | BDBM50244122 | ||
| Synonyms: | CHEMBL459457 | trans-4-(((4-tert-butylcyclohexyl)(1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H34N8O | ||
| Mol. Mass. | 486.6119 | ||
| SMILES | Cn1c(nc2ccccc12)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C |r,wU:26.29,wD:29.36,(21.92,-38.87,;22.27,-37.38,;23.7,-36.78,;23.58,-35.25,;22.08,-34.89,;21.34,-33.54,;19.8,-33.5,;19,-34.82,;19.74,-36.17,;21.27,-36.2,;25.03,-37.56,;25.02,-39.1,;26.35,-39.88,;27.68,-39.11,;29.01,-39.89,;29,-41.43,;27.66,-42.19,;26.33,-41.41,;30.33,-42.21,;30.32,-43.75,;31.67,-41.45,;33,-42.22,;33.52,-43.67,;35.06,-43.64,;35.5,-42.16,;34.23,-41.29,;26.36,-36.8,;26.36,-35.26,;27.71,-34.5,;29.04,-35.28,;29.02,-36.82,;27.69,-37.58,;30.38,-34.53,;31.7,-33.74,;31.15,-35.86,;29.61,-33.19,)| | ||
| Structure | 
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