Reaction Details |
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Target | Cyclin-dependent kinase 2-associated protein 1 |
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Ligand | BDBM50243332 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_491562 (CHEMBL944208) |
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IC50 | >100000±n/a nM |
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Citation | Janetka, JW; Almeida, L; Ashwell, S; Brassil, PJ; Daly, K; Deng, C; Gero, T; Glynn, RE; Horn, CL; Ioannidis, S; Lyne, P; Newcombe, NJ; Oza, VB; Pass, M; Springer, SK; Su, M; Toader, D; Vasbinder, MM; Yu, D; Yu, Y; Zabludoff, SD Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors. Bioorg Med Chem Lett18:4242-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2-associated protein 1 |
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Name: | Cyclin-dependent kinase 2-associated protein 1 |
Synonyms: | CDK2AP1 | CDKA1_HUMAN | CDKAP1 | DOC1 |
Type: | PROTEIN |
Mol. Mass.: | 12370.40 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_491562 |
Residue: | 115 |
Sequence: | MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQ
SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS
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BDBM50243332 |
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n/a |
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Name | BDBM50243332 |
Synonyms: | 1-(5-(4-(2-(diethylamino)ethoxy)phenyl)-3-((3-(hydroxymethyl)phenyl)carbamoyl)thiophen-2-yl)urea | CHEMBL452020 |
Type | Small organic molecule |
Emp. Form. | C25H30N4O4S |
Mol. Mass. | 482.595 |
SMILES | CCN(CC)CCOc1ccc(cc1)-c1cc(C(=O)Nc2cccc(CO)c2)c(NC(N)=O)s1 |
Structure |
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