Reaction Details |
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Target | Falcipain 2 |
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Ligand | BDBM50243232 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_491630 (CHEMBL945401) |
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IC50 | 2±n/a nM |
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Citation | Verissimo, E; Berry, N; Gibbons, P; Cristiano, ML; Rosenthal, PJ; Gut, J; Ward, SA; O'Neill, PM Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorg Med Chem Lett18:4210-4 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Falcipain 2 |
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Name: | Falcipain 2 |
Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
Type: | Enzyme |
Mol. Mass.: | 55912.60 |
Organism: | Plasmodium falciparum |
Description: | Recombinant falcipain-2. |
Residue: | 484 |
Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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BDBM50243232 |
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n/a |
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Name | BDBM50243232 |
Synonyms: | CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo-1-((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-ylamino)pentan-2-yl)morpholine-4-carboxamide | N~2~-(MORPHOLIN-4-YLCARBONYL)-N~1~-[(1S,2E)-1-(2-PHENYLETHYL)-3-(PHENYLSULFONYL)PROP-2-ENYL]-D-LEUCINAMIDE |
Type | Small organic molecule |
Emp. Form. | C28H37N3O5S |
Mol. Mass. | 527.675 |
SMILES | CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1 |r,w:27.29| |
Structure |
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