Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50242923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_487421 (CHEMBL1020015) |
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Ki | 745±n/a nM |
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Citation | Mahaney, PE; Gavrin, LK; Trybulski, EJ; Stack, GP; Vu, TA; Cohn, ST; Ye, F; Belardi, JK; Santilli, AA; Sabatucci, JP; Leiter, J; Johnston, GH; Bray, JA; Burroughs, KD; Cosmi, SA; Leventhal, L; Koury, EJ; Zhang, Y; Mugford, CA; Ho, DM; Rosenzweig-Lipson, SJ; Platt, B; Smith, VA; Deecher, DC Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. J Med Chem51:4038-49 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50242923 |
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n/a |
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Name | BDBM50242923 |
Synonyms: | 1-[1-(3-Methoxyphenyl)-2-piperazin-1-ylethyl]cyclohexanol Dihydrochloride | CHEMBL469460 |
Type | Small organic molecule |
Emp. Form. | C19H30N2O2 |
Mol. Mass. | 318.4537 |
SMILES | COc1cccc(c1)C(CN1CCNCC1)C1(O)CCCCC1 |
Structure |
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