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TargetSodium-dependent noradrenaline transporter
LigandBDBM50010884
Substrate/Competitorn/a
Meas. Tech.ChEMBL_487421 (CHEMBL1020015)
Ki 21±n/a nM
Citation Mahaney, PEGavrin, LKTrybulski, EJStack, GPVu, TACohn, STYe, FBelardi, JKSantilli, AASabatucci, JPLeiter, JJohnston, GHBray, JABurroughs, KDCosmi, SALeventhal, LKoury, EJZhang, YMugford, CAHo, DMRosenzweig-Lipson, SJPlatt, BSmith, VADeecher, DC Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. J Med Chem51:4038-49 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:P23975
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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  Blast E-value cutoff:
BDBM50010884
n/a
NameBDBM50010884
Synonyms:1-(2-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)ethyl)cyclohexanol | 1-[2-Dimethylamino-1-(3-trifluoromethyl-phenyl)-ethyl]-cyclohexanol (HCl) | CHEMBL99653
TypeSmall organic molecule
Emp. Form.C17H24F3NO
Mol. Mass.315.3738
SMILESCN(C)CC(c1cccc(c1)C(F)(F)F)C1(O)CCCCC1
Structure
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