Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50243501 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_487432 (CHEMBL1020887) |
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Ki | 45±n/a nM |
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Citation | Mahaney, PE; Gavrin, LK; Trybulski, EJ; Stack, GP; Vu, TA; Cohn, ST; Ye, F; Belardi, JK; Santilli, AA; Sabatucci, JP; Leiter, J; Johnston, GH; Bray, JA; Burroughs, KD; Cosmi, SA; Leventhal, L; Koury, EJ; Zhang, Y; Mugford, CA; Ho, DM; Rosenzweig-Lipson, SJ; Platt, B; Smith, VA; Deecher, DC Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. J Med Chem51:4038-49 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM50243501 |
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n/a |
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Name | BDBM50243501 |
Synonyms: | 1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol Dihydrochloride | CHEMBL461705 |
Type | Small organic molecule |
Emp. Form. | C18H27ClN2O |
Mol. Mass. | 322.873 |
SMILES | OC1(CCCCC1)C(CN1CCNCC1)c1cccc(Cl)c1 |
Structure |
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