| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM50251439 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_490329 (CHEMBL982026) |
|---|
| IC50 | 5±n/a nM |
|---|
| Citation |  Hagmann, WK The many roles for fluorine in medicinal chemistry. J Med Chem51:4359-69 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36975.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43235 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM50251439 |
|---|
| n/a |
|---|
| Name | BDBM50251439 |
|---|
| Synonyms: | 1-[(S)-2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4-yl)-ethylamino]-cyclohexanecarboxylic acid cyanomethyl-amide | CHEMBL479755 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H32F3N5O |
|---|
| Mol. Mass. | 499.5711 |
|---|
| SMILES | FC(F)(F)[C@@H](NC1(CCCCC1)C(=O)NCC#N)c1ccc(cc1)-c1ccc(cc1)N1CCNCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
