Reaction Details |
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Target | Egl nine homolog 1 |
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Ligand | BDBM50251959 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_488018 (CHEMBL983035) |
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IC50 | 3±n/a nM |
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Citation | Tegley, CM; Viswanadhan, VN; Biswas, K; Frohn, MJ; Peterkin, TA; Chang, C; Bürli, RW; Dao, JH; Veith, H; Rogers, N; Yoder, SC; Biddlecome, G; Tagari, P; Allen, JR; Hungate, RW Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation. Bioorg Med Chem Lett18:3925-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Egl nine homolog 1 |
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Name: | Egl nine homolog 1 |
Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
Type: | Protein |
Mol. Mass.: | 46035.59 |
Organism: | Homo sapiens (Human) |
Description: | Q9GZT9 |
Residue: | 426 |
Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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BDBM50251959 |
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n/a |
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Name | BDBM50251959 |
Synonyms: | 2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-hydroxy-2,3-dihydrothiazol-4-yl)acetic acid | CHEMBL520935 |
Type | Small organic molecule |
Emp. Form. | C18H22N2O6S2 |
Mol. Mass. | 426.507 |
SMILES | CC(C)(C)c1ccc(CS(=O)(=O)CC(=O)N=c2scc(CC(O)=O)n2O)cc1 |w:15.14| |
Structure |
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