Reaction Details |
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Target | Lysine--tRNA ligase |
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Ligand | BDBM50249539 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_490569 (CHEMBL981176) |
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IC50 | 4±n/a nM |
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Citation | Hirabayashi, A; Mukaiyama, H; Kobayashi, H; Shiohara, H; Nakayama, S; Ozawa, M; Miyazawa, K; Misawa, K; Ohnota, H; Isaji, M A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives. Bioorg Med Chem16:7347-57 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine--tRNA ligase |
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Name: | Lysine--tRNA ligase |
Synonyms: | KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 68044.78 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_960665 |
Residue: | 597 |
Sequence: | MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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BDBM50249539 |
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n/a |
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Name | BDBM50249539 |
Synonyms: | 5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide | 5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-[1,2,4]triazolo[1,5-f]pyrimidine-8-carboxamide | CHEMBL475575 | cis-5-(2-Aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-1,2,4-triazolo[1,5-c]pyrimidine-8-carboxamide |
Type | Small organic molecule |
Emp. Form. | C20H26N8O3 |
Mol. Mass. | 426.4722 |
SMILES | COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 |r| |
Structure |
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