| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ZAP-70 |
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| Ligand | BDBM50263121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_490570 (CHEMBL981177) |
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| IC50 | 97±n/a nM |
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| Citation |  Hirabayashi, A; Mukaiyama, H; Kobayashi, H; Shiohara, H; Nakayama, S; Ozawa, M; Miyazawa, K; Misawa, K; Ohnota, H; Isaji, M A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives. Bioorg Med Chem16:7347-57 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ZAP-70 |
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| Name: | Tyrosine-protein kinase ZAP-70 |
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| Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
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| Type: | Enzyme |
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| Mol. Mass.: | 69881.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
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| Residue: | 619 |
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| Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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| BDBM50263121 |
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| n/a |
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| Name | BDBM50263121 |
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| Synonyms: | CHEMBL472840 | cis-5-(2-Aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-2-(2-chlorophenyl)-1,2,4-triazolo[1,5-c]pyrimidine-8-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29ClN8O3 |
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| Mol. Mass. | 537.013 |
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| SMILES | COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3nc(nc3c2C(N)=O)-c2ccccc2Cl)cc(OC)c1 |r| |
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| Structure | 
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