| Reaction Details |
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 | Report a problem with these data |
| Target | C5a anaphylatoxin chemotactic receptor 1 |
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| Ligand | BDBM50251748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_488511 (CHEMBL991044) |
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| IC50 | 290±n/a nM |
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| Citation |  Gong, Y; Barbay, JK; Buntinx, M; Li, J; Wauwe, JV; Claes, C; Lommen, GV; Hornby, PJ; He, W Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists. Bioorg Med Chem Lett18:3852-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C5a anaphylatoxin chemotactic receptor 1 |
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| Name: | C5a anaphylatoxin chemotactic receptor 1 |
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| Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39347.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21730 |
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| Residue: | 350 |
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| Sequence: | MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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| BDBM50251748 |
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| n/a |
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| Name | BDBM50251748 |
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| Synonyms: | 2-(2,6-diethylphenyl)-4-methoxy-N-(2-methyl-5-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroquinolin-5-amine | CHEMBL480156 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31F3N2O |
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| Mol. Mass. | 468.5537 |
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| SMILES | CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cc(ccc1C)C(F)(F)F |
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| Structure | 
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