Reaction Details |
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Target | Lysosomal alpha-mannosidase |
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Ligand | BDBM50263050 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_489066 (CHEMBL987286) |
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IC50 | 150000±n/a nM |
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Citation | Fiaux, H; Kuntz, DA; Hoffman, D; Janzer, RC; Gerber-Lemaire, S; Rose, DR; Juillerat-Jeanneret, L Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. Bioorg Med Chem16:7337-46 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal alpha-mannosidase |
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Name: | Lysosomal alpha-mannosidase |
Synonyms: | LAMAN | MA2B1_HUMAN | MAN2B1 | MANB |
Type: | PROTEIN |
Mol. Mass.: | 113753.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1432452 |
Residue: | 1011 |
Sequence: | MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQP
NMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVE
IAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLE
DTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWR
ASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVA
TAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYL
WELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
LAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNAL
ARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDP
NGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRS
WSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAY
IFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIP
VGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNT
RIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRG
RHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSV
HLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ
LREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
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BDBM50263050 |
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n/a |
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Name | BDBM50263050 |
Synonyms: | (R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate | CHEMBL476927 |
Type | Small organic molecule |
Emp. Form. | C20H21BrN2O5 |
Mol. Mass. | 449.295 |
SMILES | O[C@@H]1[C@@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)NC(=O)[C@@H]1O |r| |
Structure |
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