| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50262974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_490152 (CHEMBL983811) |
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| IC50 | 21±n/a nM |
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| Citation |  Angell, R; Aston, NM; Bamborough, P; Buckton, JB; Cockerill, S; deBoeck, SJ; Edwards, CD; Holmes, DS; Jones, KL; Laine, DI; Patel, S; Smee, PA; Smith, KJ; Somers, DO; Walker, AL Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg Med Chem Lett18:4428-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50262974 |
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| n/a |
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| Name | BDBM50262974 |
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| Synonyms: | 6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopropylamide 4'-[4-(4-methyl-piperazin-1-yl)-benzylamide] | CHEMBL516127 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N4O2 |
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| Mol. Mass. | 482.6166 |
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| SMILES | CN1CCN(CC1)c1ccc(CNC(=O)c2ccc(cc2)-c2cc(ccc2C)C(=O)NC2CC2)cc1 |
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| Structure | 
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