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TargetCyclin-dependent kinase 2
LigandBDBM50263147
Substrate/Competitorn/a
Meas. Tech.ChEMBL_490603
IC50 0.5±n/a nM
Citation Finlay MRActon DGAndrews DMBarker AJDennis MFisher EGraham MAGreen CPHeaton DWKaroutchi GLoddick SAMorgentin RRoberts ATucker JAWeir HM Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode. Bioorg Med Chem Lett 18:4442-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50263147
n/a
NameBDBM50263147
Synonyms:CHEMBL476577 | N-(1-(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)phenyl)azetidin-3-yl)acetamide
TypeSmall organic molecule
Emp. Form.C22H26FN7O
Mol. Mass.423.4865
SMILESCC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)N2CC(C2)NC(C)=O)ncc1F
Structure
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