Reaction Details |
| Report a problem with these data |
Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
---|
Ligand | BDBM50266744 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_564957 (CHEMBL957492) |
---|
Ki | 4200±n/a nM |
---|
Citation | McCarthy, O; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Perez, LM; Johansson, NG; Pacanowska, DG; Gilbert, IH Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. Eur J Med Chem44:678-88 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Deoxyuridine 5'-triphosphate nucleotidohydrolase |
---|
Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
Synonyms: | dUTP pyrophosphatase |
Type: | Protein |
Mol. Mass.: | 19574.43 |
Organism: | Plasmodium falciparum |
Description: | Q8II92 |
Residue: | 173 |
Sequence: | MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
|
|
|
BDBM50266744 |
---|
n/a |
---|
Name | BDBM50266744 |
Synonyms: | 1-((2R,4S,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL513890 |
Type | Small organic molecule |
Emp. Form. | C25H30N2O5Si |
Mol. Mass. | 466.6016 |
SMILES | CC(C)(C)[Si](OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 |r| |
Structure |
|