| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein 4 |
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| Ligand | BDBM50262127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_490878 (CHEMBL989154) |
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| IC50 | 350±n/a nM |
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| Citation |  Cuny, GD; Yu, PB; Laha, JK; Xing, X; Liu, JF; Lai, CS; Deng, DY; Sachidanandan, C; Bloch, KD; Peterson, RT Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett18:4388-92 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein 4 |
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| Name: | Bone morphogenetic protein 4 |
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| Synonyms: | BMP2B | BMP4 | BMP4_HUMAN | DVR4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46572.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363193 |
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| Residue: | 408 |
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| Sequence: | MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT
LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF
HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI
YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH
LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR
ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL
VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
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| BDBM50262127 |
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| n/a |
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| Name | BDBM50262127 |
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| Synonyms: | 7-chloro-4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | CHEMBL468399 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21ClN6 |
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| Mol. Mass. | 440.927 |
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| SMILES | Clc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 |
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| Structure | 
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