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TargetCytochrome P450 2D6 (2D6)
LigandBDBM50262510
Substrate/Competitorn/a
Meas. Tech.ChEMBL_514340
Ki 120±n/a nM
Citation Shishido YWakabayashi HKoike HUeno NNukui SYamagishi TMurata YNaganeo FMizutani MShimada KFujiwara YSakakibara ASuga OKusano RUeda SKanai YTsuchiya MSatake K Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'. Bioorg Med Chem 16:7193-205 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50262510
n/a
NameBDBM50262510
Synonyms:CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene)-7-yl)]methylamino-2-phenylpiperidine | R/S-(2S,3S)-N-((3-methoxy-8-methyl-8-(trifluoromethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)-2-phenylpiperidin-3-amine
TypeSmall organic molecule
Emp. Form.C25H31F3N2O
Mol. Mass.432.5216
SMILESCOc1cc2CCCC(C)(c2cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(F)(F)F |r|
Structure
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