Ki Summary

Reaction Details

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Target

Glutamate racemase

Ligand

BDBM50261913

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_514356 (CHEMBL967970)

IC50

57±n/a nM

Citation

Basarab, GS; Hill, PJ; Rastagar, A; Webborn, PJ Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: a novel pro-drug approach to increase exposure. Bioorg Med Chem Lett18:4716-22 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glutamate racemase

Name:

Glutamate racemase

Synonyms:

MURI_HELPY | glr | murI

Type:

PROTEIN

Mol. Mass.:

28413.39

Organism:

Helicobacter pylori

Description:

ChEMBL_475324

Residue:

255

Sequence:

MKIGVFDSGVGGFSVLKSLLKAQLFDEIIYYGDSARVPYGTKDPTTIKQFGLEALDFFKP
HQIKLLIVACNTASALALEEMQKHSKIPVVGVIEPSILAIKRQVKDKNAPILVLGTKATI
QSNAYDNALKQQGYLNVSHLATSLFVPLIEESILEGELLETCMRYYFTPLEILPEVVILG
CTHFPLIAQKIEGYFMEHFALSTPPLLIHSGDAIVEYLQQNYALKKNACAFPKVEFHASG
DVVWLEKQAKEWLKL

BDBM50261913

n/a

Name

BDBM50261913

Synonyms:

2-((5-chloro-1-methyl-1H-indol-3-yl)methyl)-7-(cyclopropylmethyl)-5-methyl-3-(2-methyl-5-(methylsulfonyl)furan-3-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | CHEMBL467803

Type

Small organic molecule

Emp. Form.

C26H26ClN5O5S

Mol. Mass.

556.033

SMILES

Cc1oc(cc1-c1n(Cc2cn(C)c3ccc(Cl)cc23)nc2n(CC3CC3)c(=O)n(C)c(=O)c12)S(C)(=O)=O |(19.66,-27.53,;21.2,-27.53,;22.1,-26.29,;23.56,-26.76,;23.57,-28.29,;22.1,-28.77,;21.63,-30.24,;22.54,-31.49,;24.08,-31.49,;24.85,-32.82,;24.23,-34.23,;25.38,-35.26,;25.22,-36.79,;26.71,-34.49,;28.16,-34.96,;29.31,-33.93,;28.98,-32.43,;30.12,-31.39,;27.52,-31.96,;26.39,-32.98,;21.63,-32.74,;20.16,-32.27,;18.81,-33.03,;18.81,-34.57,;17.47,-35.34,;15.94,-35.34,;16.71,-36.68,;17.48,-32.26,;16.15,-33.03,;17.48,-30.71,;16.14,-29.95,;18.81,-29.94,;18.81,-28.4,;20.16,-30.71,;24.8,-25.85,;26.13,-25.07,;23.96,-24.56,;25.65,-27.13,)|

Structure