| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Ligand | BDBM50135594 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_509577 (CHEMBL1000463) |
|---|
| Ki | 0.27±n/a nM |
|---|
| Citation |  Rizzi, L; Dallanoce, C; Matera, C; Magrone, P; Pucci, L; Gotti, C; Clementi, F; De Amici, M Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. Bioorg Med Chem Lett18:4651-4 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70196.44 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P09483 |
|---|
| Residue: | 630 |
|---|
| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
|
|
|
|---|
| BDBM50135594 |
|---|
| n/a |
|---|
| Name | BDBM50135594 |
|---|
| Synonyms: | (+/-)-2-(6-chloropyridin-3-yl)-9-aza-bicyclo[4.2.1]non-2-ene | 2-(6-Chloro-pyridin-3-yl)-9-aza-bicyclo[4.2.1]non-2-ene | CHEMBL63102 | UB-165 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H15ClN2 |
|---|
| Mol. Mass. | 234.725 |
|---|
| SMILES | Clc1ccc(cn1)C1=CCCC2CCC1N2 |t:8,THB:4:7:12.13:15| |
|---|
| Structure | 
|
|---|
Search and Browse
