| Reaction Details |
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 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
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| Ligand | BDBM50273036 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513688 (CHEMBL974538) |
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| IC50 | 14±n/a nM |
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| Citation |  Hebeisen, P; Kuhn, B; Kohler, P; Gubler, M; Huber, W; Kitas, E; Schott, B; Benz, J; Joseph, C; Ruf, A Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett18:4708-12 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fructose-1,6-bisphosphatase 1 |
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| Name: | Fructose-1,6-bisphosphatase 1 |
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| Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
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| Type: | Protein |
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| Mol. Mass.: | 36843.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Liver FBPase (P09467) |
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| Residue: | 338 |
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| Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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| BDBM50273036 |
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| n/a |
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| Name | BDBM50273036 |
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| Synonyms: | 1-[(3-chlorobenzene)sulfonyl]-3-[(3E)-6-({[(3-chlorobenzene)sulfonyl]carbamoyl}amino)hex-3-en-1-yl]urea | CHEMBL456564 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22Cl2N4O6S2 |
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| Mol. Mass. | 549.448 |
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| SMILES | Clc1cccc(c1)S(=O)(=O)NC(=O)NCC\C=C\CCNC(=O)NS(=O)(=O)c1cccc(Cl)c1 |
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| Structure | 
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