| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 1 of Calcitonin receptor (1) |
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| Ligand | BDBM50268484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_509836 (CHEMBL1000517) |
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| Ki | >5000±n/a nM |
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| Citation |  Degnan, AP; Chaturvedula, PV; Conway, CM; Cook, DA; Davis, CD; Denton, R; Han, X; Macci, R; Mathias, NR; Moench, P; Pin, SS; Ren, SX; Schartman, R; Signor, LJ; Thalody, G; Widmann, KA; Xu, C; Macor, JE; Dubowchik, GM Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and effic J Med Chem51:4858-61 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 1 of Calcitonin receptor (1) |
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| Name: | Isoform 1 of Calcitonin receptor (1) |
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| Synonyms: | CALCR | CALCR_HUMAN | CT-R | Calcitonin receptor | Calcitonin receptor (1) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55343.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_42610 |
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| Residue: | 474 |
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| Sequence: | MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
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| BDBM50268484 |
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| n/a |
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| Name | BDBM50268484 |
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| Synonyms: | (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide | (R)-N-(1-(1,4'-bipiperidin-1'-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamide | BMS-694153 | CHEMBL450668 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H45FN8O3 |
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| Mol. Mass. | 644.782 |
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| SMILES | Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r| |
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| Structure | 
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