Ki Summary

Reaction Details

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Target

Hydroxycarboxylic acid receptor 2

Ligand

BDBM50273099

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_509912 (CHEMBL1002182)

EC50

2300±n/a nM

Citation

Semple, G; Skinner, PJ; Gharbaoui, T; Shin, YJ; Jung, JK; Cherrier, MC; Webb, PJ; Tamura, SY; Boatman, PD; Sage, CR; Schrader, TO; Chen, R; Colletti, SL; Tata, JR; Waters, MG; Cheng, K; Taggart, AK; Cai, TQ; Carballo-Jane, E; Behan, DP; Connolly, DT; Richman, JG 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice. J Med Chem51:5101-8 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hydroxycarboxylic acid receptor 2

Name:

Hydroxycarboxylic acid receptor 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

41476.06

Organism:

Rattus norvegicus

Description:

ChEMBL_820675

Residue:

360

Sequence:

MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSR
IFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAV
DRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSIC
YTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVIC
FLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPN
FFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR

BDBM50273099

n/a

Name

BDBM50273099

Synonyms:

3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole | 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole | CHEMBL456145 | MK-0354

Type

Small organic molecule

Emp. Form.

C7H8N6

Mol. Mass.

176.1786

SMILES

C1Cc2[nH]nc(c2C1)-c1nnn[nH]1

Structure