Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50273229 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_510032 (CHEMBL995175) |
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Ki | 14±n/a nM |
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Citation | Uchida, M; Okazaki, K; Mukaiyama, H; Isawa, H; Kobayashi, H; Shiohara, H; Muranaka, H; Kai, Y; Kikuchi, N; Takeuchi, H; Yokoyama, K; Tsuji, E; Ozawa, T; Hoyano, Y; Koizumi, T; Misawa, K; Hara, K; Nakano, S; Murakami, Y; Okuno, H Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy. Bioorg Med Chem Lett18:4682-7 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50273229 |
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n/a |
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Name | BDBM50273229 |
Synonyms: | CHEMBL455916 | {(5-Carbamimidoyl-2-hydroxy-benzenesulfonyl)-[2-(4-isopropyl-phenyl)-ethyl]-amino}-acetic acid |
Type | Small organic molecule |
Emp. Form. | C20H25N3O5S |
Mol. Mass. | 419.495 |
SMILES | CC(C)c1ccc(CCN(CC(O)=O)S(=O)(=O)c2cc(ccc2O)C(N)=N)cc1 |
Structure |
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