| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50245445 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_512836 |
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| IC50 | >100000±n/a nM |
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| Citation |  Hughes TV; Xu G; Wetter SK; Connolly PJ; Emanuel SL; Karnachi P; Pollack SR; Pandey N; Adams M; Moreno-Mazza S; Middleton SA; Greenberger LM A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity. Bioorg Med Chem Lett 18:4896-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1/G1/S-specific cyclin-D1 |
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| Synonyms: | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50245445 |
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| n/a |
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| Name | BDBM50245445 |
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| Synonyms: | 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carbohydrazide | CHEMBL511478 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClN6O2 |
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| Mol. Mass. | 384.82 |
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| SMILES | NNC(=O)c1c(N)ncnc1Nc1ccc(OCc2ccccc2)c(Cl)c1 |
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| Structure | 
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