| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
|---|
| Ligand | BDBM50245186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_513421 (CHEMBL976508) |
|---|
| EC50 | 0.11±n/a nM |
|---|
| Citation |  Berger, R; Zhu, C; Hansen, AR; Harper, B; Chen, Z; Holt, TG; Hubert, J; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; Wolff, M; Macneil, DJ; Weber, AE; Edmondson, SD 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity. Bioorg Med Chem Lett18:4833-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholecystokinin receptor type A |
|---|
| Name: | Cholecystokinin receptor type A |
|---|
| Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR_MOUSE | Cckar | Cholecystokinin A receptor | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48454.29 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_40042 |
|---|
| Residue: | 436 |
|---|
| Sequence: | MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGI
KFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGCYLQKSRPPRKLELQQLSTSSSGGR
INRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPI
SFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVGEEEDGRTIRAS
LSRYSYSHMSTSAPPH
|
|
|
|---|
| BDBM50245186 |
|---|
| n/a |
|---|
| Name | BDBM50245186 |
|---|
| Synonyms: | 3-((S)-4-(1-(3-ethoxyphenyl)-2-p-tolyl-1H-imidazole-4-carbonyl)-3-(isopropylcarbamoyl)piperazin-1-yl)-1-naphthoic acid | CHEMBL509464 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H39N5O5 |
|---|
| Mol. Mass. | 645.7468 |
|---|
| SMILES | CCOc1cccc(c1)-n1cc(nc1-c1ccc(C)cc1)C(=O)N1CCN(C[C@H]1C(=O)NC(C)C)c1cc(C(O)=O)c2ccccc2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
