| Reaction Details |
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 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
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| Ligand | BDBM50245204 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513420 (CHEMBL976507) |
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| IC50 | 0.24±n/a nM |
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| Citation |  Berger, R; Zhu, C; Hansen, AR; Harper, B; Chen, Z; Holt, TG; Hubert, J; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; Wolff, M; Macneil, DJ; Weber, AE; Edmondson, SD 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity. Bioorg Med Chem Lett18:4833-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholecystokinin receptor type A |
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| Name: | Cholecystokinin receptor type A |
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| Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 47859.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-1 receptors in HEK 293 cells. |
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| Residue: | 428 |
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| Sequence: | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
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| BDBM50245204 |
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| n/a |
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| Name | BDBM50245204 |
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| Synonyms: | (2S)-1-(1-(3-ethoxyphenyl)-2-p-tolyl-1H-imidazole-4-carbonyl)-N-isopropyl-4-(quinolin-3-yl)piperazine-2-carboxamide | CHEMBL505432 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H38N6O3 |
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| Mol. Mass. | 602.7253 |
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| SMILES | CCOc1cccc(c1)-n1cc(nc1-c1ccc(C)cc1)C(=O)N1CCN(C[C@H]1C(=O)NC(C)C)c1cnc2ccccc2c1 |r| |
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| Structure | 
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