| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
|---|
| Ligand | BDBM50244726 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_512118 (CHEMBL980054) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Scott, DA; Aquila, BM; Bebernitz, GA; Cook, DJ; Dakin, LA; Deegan, TL; Hattersley, MM; Ioannidis, S; Lyne, PD; Omer, CA; Ye, M; Zheng, X Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer. Bioorg Med Chem Lett18:4794-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage colony-stimulating factor 1 receptor |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor |
|---|
| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 107979.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07333 |
|---|
| Residue: | 972 |
|---|
| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
|
|
|
|---|
| BDBM50244726 |
|---|
| n/a |
|---|
| Name | BDBM50244726 |
|---|
| Synonyms: | 2-chloro-5-[(3,4-dichlorobenzoyl)amino]-N-pyridin-3-ylbenzamide | CHEMBL461365 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H12Cl3N3O2 |
|---|
| Mol. Mass. | 420.676 |
|---|
| SMILES | Clc1ccc(cc1Cl)C(=O)Nc1ccc(Cl)c(c1)C(=O)Nc1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
