| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
|---|
| Ligand | BDBM50069792 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_512148 (CHEMBL980942) |
|---|
| Ki | 190±n/a nM |
|---|
| Citation |  Donkor, IO; Korukonda, R Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position. Bioorg Med Chem Lett18:4806-8 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calpain-1 catalytic subunit |
|---|
| Name: | Calpain-1 catalytic subunit |
|---|
| Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
|---|
| Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
|---|
| Mol. Mass.: | 81729.82 |
|---|
| Organism: | Sus scrofa (pig) |
|---|
| Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
|---|
| Residue: | 714 |
|---|
| Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
|
|
|
|---|
| BDBM50069792 |
|---|
| n/a |
|---|
| Name | BDBM50069792 |
|---|
| Synonyms: | (2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-N-[(1S)-1-formylpentyl]-4-methylpentanamide | Acetylleucyl-leucyl-norleucinal | CHEMBL304784 | Calpain inhibitor I | N-acetylleucylleucylnorleucinal |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H37N3O4 |
|---|
| Mol. Mass. | 383.5255 |
|---|
| SMILES | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
