Reaction Details |
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Target | Calpain-1 catalytic subunit |
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Ligand | BDBM50244952 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_512148 (CHEMBL980942) |
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Ki | 80±n/a nM |
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Citation | Donkor, IO; Korukonda, R Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position. Bioorg Med Chem Lett18:4806-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calpain-1 catalytic subunit |
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Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
Mol. Mass.: | 81729.82 |
Organism: | Sus scrofa (pig) |
Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
Residue: | 714 |
Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM50244952 |
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n/a |
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Name | BDBM50244952 |
Synonyms: | (S)-2-ethyl-N-(1-oxo-3-phenylpropan-2-yl)-2-(3-phenylpropanamido)butanamide | CHEMBL513049 |
Type | Small organic molecule |
Emp. Form. | C24H30N2O3 |
Mol. Mass. | 394.5066 |
SMILES | CCC(CC)(NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O |r| |
Structure |
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