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TargetProtein kinase C alpha type
LigandBDBM50244415
Substrate/Competitorn/a
Meas. Tech.ChEMBL_512395 (CHEMBL979906)
Ki 10.1±n/a nM
Citation Duan, DSigano, DMKelley, JALai, CCLewin, NEKedei, NPeach, MLLee, JAbeyweera, TPRotenberg, SAKim, HKim, YHEl Kazzouli, SChung, JUYoung, HAYoung, MRBaker, AColburn, NHHaimovitz-Friedman, ATruman, JPParrish, DADeschamps, JRPerry, NASurawski, RJBlumberg, PMMarquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem51:5198-220 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein kinase C alpha type
Name:Protein kinase C alpha type
Synonyms:KPCA_MOUSE | Pkca | Prkca | Protein kinase C | Protein kinase C alpha | Protein kinase C alpha type
Type:Enzyme Catalytic Domain
Mol. Mass.:76858.67
Organism:MOUSE
Description:Protein kinase C 0 MOUSE::P20444
Residue:672
Sequence:
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50244415
n/a
NameBDBM50244415
Synonyms:CHEMBL506390 | rac-(E/Z)-(4-(4-chloro-3-fluorobenzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 2-ethylhexanoate | rac-(Z)-{4-[(4-Chloro-3-fluorophenyl)methylene]-2-(hydroxymethyl)-5-oxo-2-2,3-dihydrofuryl}methyl 2-Ethylhexanoate
TypeSmall organic molecule
Emp. Form.C21H26ClFO5
Mol. Mass.412.88
SMILESCCCCC(CC)C(=O)OCC1(CO)C\C(=C\c2ccc(Cl)c(F)c2)C(=O)O1
Structure
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