Reaction Details |
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Target | Protein kinase C alpha type |
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Ligand | BDBM50244415 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_512395 (CHEMBL979906) |
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Ki | 10.1±n/a nM |
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Citation | Duan, D; Sigano, DM; Kelley, JA; Lai, CC; Lewin, NE; Kedei, N; Peach, ML; Lee, J; Abeyweera, TP; Rotenberg, SA; Kim, H; Kim, YH; El Kazzouli, S; Chung, JU; Young, HA; Young, MR; Baker, A; Colburn, NH; Haimovitz-Friedman, A; Truman, JP; Parrish, DA; Deschamps, JR; Perry, NA; Surawski, RJ; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem51:5198-220 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C alpha type |
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Name: | Protein kinase C alpha type |
Synonyms: | KPCA_MOUSE | Pkca | Prkca | Protein kinase C | Protein kinase C alpha | Protein kinase C alpha type |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 76858.67 |
Organism: | MOUSE |
Description: | Protein kinase C 0 MOUSE::P20444 |
Residue: | 672 |
Sequence: | MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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BDBM50244415 |
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n/a |
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Name | BDBM50244415 |
Synonyms: | CHEMBL506390 | rac-(E/Z)-(4-(4-chloro-3-fluorobenzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 2-ethylhexanoate | rac-(Z)-{4-[(4-Chloro-3-fluorophenyl)methylene]-2-(hydroxymethyl)-5-oxo-2-2,3-dihydrofuryl}methyl 2-Ethylhexanoate |
Type | Small organic molecule |
Emp. Form. | C21H26ClFO5 |
Mol. Mass. | 412.88 |
SMILES | CCCCC(CC)C(=O)OCC1(CO)C\C(=C\c2ccc(Cl)c(F)c2)C(=O)O1 |
Structure |
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